Pharmacodynamics: - Cefuroxime is a semisynthetic broad spectrum antibiotic of cephalosporin group. Cefuroxime has antibacterial activity due to inhibition of bacterial cell wall synthesis.
- Antibacterial spectrum: Cefuroxime has antibacterial activity on many common pathogens, including beta-lactamase secretion strains, cephalosporinase of Gram-positive and Gram-negative bacteria. Cefuroxim is particularly durable with many beta-lactamase enzymes of Gram-negative bacteria.
- Cefuroxim is usually active with the following bacteria:
Gram negative gas: E. coli, Klebsiella sp, Proteus mirabilis, providencia sp, proteus rettgeri, Haemophilus influenzae (including resistant strains of ampicillin), Haemophilus parainfluenzae, Branhamella catarrhalis, Neisseria gonorrhoeae (including strains that produce penicillinase and do not produce penicillinase).
Gram-positive aerosol: Staphylococcus aureus and Staphylococcus epidermidis (including penicillinase-producing strains except methicilline-resistant strains), Group B Streptococcus (Streptococcus agalactiae).
Anaerobic: gram-positive and gram-negative cocci (including Peptococcus and Peptostreptococcus spp). Gram-positive bacilli (including Clostridium sp) and gram-negative bacilli (including Bacteroides and Fusobacterium spp), Propionibacterium sp.
- Cefuroxime is absorbed from the gastrointestinal tract after drinking. Cefuroxim is widely distributed throughout the body. Drug through the blood brain barrier when the meninges are inflamed. The drug crosses the placenta and is excreted in breast milk. The maximum concentration in serum is achieved about 2-3 hours after taking it with a meal. Serum half-life is from 1 to 1.5 hours. Cefuroxim is not metabolized and is eliminated in unmodified form by about 50% through glomerular filtration and 50% renal tubular secretion.
Contraindications: Hypersensitivity to cephalosporin antibiotics. For patients with hypersensitivity to penicillin antibiotics, cross-allergy should be considered.
- Common: diarrhea, lumpy skin
- Rarely: nausea, vomiting, eosinophilia, leukopenia, urticaria, pruritus.
- Rarely: hemolytic anemia, pseudomembranous colitis.
Notify the Doctor of unwanted effects encountered when using medication.
Caution: - There have been reports of pseudomembranous colitis when using a broad-spectrum antibiotic so care should be taken on this diagnosis in patients with severe diarrhea associated with antibiotic use. This drug should be used with caution in gastrointestinal patients, especially colitis.
- Prolonged treatment with cefuroxime may increase the production of insensitive bacteria. Need to monitor patients carefully. If severe infection occurs during treatment, the drug must be discontinued.
- Caution should be exercised when giving patients concurrently with strong diuretics because of adverse effects on kidney function.
- Pregnant women and nursing mothers: There are no adequate studies on the use of drugs for pregnant women. Caution should be used; should consider the benefits to the mother with the danger to the fetus. Cefuroxim excreted in breast milk, should stop breastfeeding during treatment.
Drug interactions: - Ranitidin, sodium bicarbonate: reduces the bioavailability of cefuroxim. Cefuroxime should be taken at least 2 hours after antacids or H2 blockers, as it may increase gastric pH.
- Probenecid in high doses reduces cefuroxime clearance in the kidneys, making plasma concentration cefuroxime higher and longer.
- Aminoglycosides increase the likelihood of causing kidney toxicity.
Storage: Store in a cool, dry place, protected from light.
- Duration of treatment from 5-10 days.
- Should take pms-Zanimex after meals to achieve optimal absorption. Swallow the whole pill, not chewed by bitter taste.
- Most infections: 250 mg twice daily.
- Urinary infections: 125 mg twice daily.
- Lower respiratory infections: 250 - 500 mg twice daily.
- Renal inflammation - renal pelvis: 250 mg twice daily.
- Uncomplicated gonorrhea: single dose of 1g
- Most infections: 125 mg twice daily, up to 250 mg / day.
- Children 2 years of age and older with otitis media or more severe infections: 250 mg twice daily, up to 500 mg / day.
- Pms-Zanimex tablets are not suitable for use by patients who cannot swallow the whole tablet. No experience using pms-Zanimex for children under 3 months old.