Crapio Inj.

• Ingredients: Each vial contains USP Ceftriaxone Sterile Sodium equivalent to 1g Ceftriaxone (active) ..
  Clinical pharmacology: Ceftriaxone is a third-generation Cephalosporine with a broad spectrum of antibacterial activity. It is difficult to decompose and is not inactivated by Beta-lactamase. Ceftriaxone is used in sodium salt for injection. Ceftriaxone is an antiseptic. As with other Beta-lactam, Ceftriaxone kills bacteria by inhibiting the synthesis of bacterial cell walls.
• Antimicrobial activity:
  - Ceftriaxone is stable with Beta-lactamases including Penicillinase and Cephalosporinase produced by gram-negative and gram-positive bacteria. Ceftriaxone works against most gram negative and gram positive anaerobic bacteria and with some anaerobic bacteria.
  - Gram-positive bacteria

Ceftriaxone has a very strong effect against S. pneumoniae, Group A and B. Streptococci. Other gram-positive bacteria sensitive to Ceftriaxone include Staphylococcus aureus including penicillinase and Staphylococcus epidermidis.
- Gram negative bacteria
Sensitive bacteria including E.coli, Citrobacter freundii, C.diversus, Klebsiella spp., K. pneumoniae, Enterobacter spp, E. aerogenes, E. cloacae, Serratia spp., Serratia marcescens, proteus mirabillis, Providencia spp., Salmonella spp., Shigelle spp., Morganella morganii, P. vulgaris.
Neiseria including Neiseria gonorhoaea and N. meningitidis give birth and give birth to Penicillinase is sensitive to Ceftriaxone. Haemophilus influenzae including Ampicilin-resistant strains are also sensitive to ceftriaxone.
- Anaerobic bacteria
Ceftriaxone has no activity against Bacteroides fragillis, B. melaninogenicus, B. bivius, Clostridium spp., And Peptostreptococci. Ceftriaxone has a similar activity against Treponema similar to Benzyl Penicillin and has very strong activity against Borella burgdorferi.

• Pharmacokinetics:
  - Ceftriaxone is completely absorbed after intramuscular injection with the maximum concentration in plasma achieved 2-3 hours after injection. When taking Ceftriaxone for intravenous administration, the plasma content is significantly higher. After intramuscular administration of a single dose of 0.5g and 1.0g, the mean plasma content in plasma after 30 minutes was 30 and 40 mcg / ml, after 2 hours was 43 and 76 mcg / ml, after 4 hours 39 and 68 mcg / ml and after 12 hours were 16 and 29 mcg / ml, respectively. Ceftriaxone plasma half-life does not depend on the dose and varies from 6 to 9 hours. 85-95% of Ceftriaxone binds with plasma proteins. Ceftriaxone penetrates well into most tissues and fluids in the body including cerebrospinal fluid (inflamed or non-inflamed meninges). High content achieved in honey.
  - Ceftriaxone is not metabolized in the body. 33-67% of the dose is eliminated intact through the urine. The remainder is excreted intact through the bile and eventually excreted in the form of inactive compounds.
  - Half-life only changes slightly in the elderly or patients with kidney or liver dysfunction. However, it increases in newborns.
• Indication: Ceftriaxone is indicated for:
  - Infections of the lower respiratory tract and pneumonia.
  - Bacterial tract infections.
  - Serious infections with or without septicemia.
  - Bacterial meningitis
  - Pelvic inflammatory diseases
  - Skin and soft tissue infections.
  - Bone-joint infection
  - Sexually transmitted infections.
  - Prevention of infection in surgery.
• Instructions for use: Inject corn
  - Intramuscular solution Ceftriaxone is prepared by adding 3.6 ml of the following solutions: distilled water used for injection; Sodium Chloride 0.9% injection; Dextrose 5% injection; Bacterial water to inject 0.9% benzyl alcohol or 1% Lidocaine Hydrochlorid into a 1 g bottle of Ceftriaxone, to obtain a 250 mg / ml solution. More diluted drug solutions can be used for intramuscular administration if necessary.
  Intermittent intravenous infusion
  For intermittent intravenous infusion, 1 g Ceftriaxone vials were mixed with 9.6 ml of a compatible intravenous infusion, to give a solution of about 100 mg / ml. The drug solution must then be further diluted with a compatible intravenous solution for a concentration of 10-40 mg / ml although a more diluted solution may be used, if necessary.